Collaboration
Genomics of Immune Cells
Vladimir Benes, PhD, European Molecular Biology Laboratory, Heidelberg, Germany
Dr. Benes is a head of the Genomic Core facility at the European Molecular Biology Laboratory, Heidelberg, Germany, a European center of excellence for genomic services and research. He is an organizer of various training activities in genomics laboratory methods and provides support in experimental design involving genomics approaches. Dr. Benes is a long-term mentor of the PI. She spent a research fellowship and carried out several scientific visits at the Genomic Core facility, and her students have been trained at the same place as well.
Collaboration:
Prof. Richard Rosenquist, MD, PhD, Karolinska Institutet, Karolinska Univesity Hospital, Sweden
Prof. Rosenquist is an appointed Professor of Clinical Genetics at the Department of Molecular Medicine and Surgery, Karolinska Institutet and Senior Physician in Clinical Genetics at Karolinska University Hospital, Stockholm, Sweden. He has initiated and led the SciLifeLab Clinical Genomics Facility in Uppsala and is currently Platform Director for the national Diagnostics Development Platform within SciLifeLab. More recently, he is coordinating the Genomics Medicine Sweden initiative that aims to build a new type of infrastructure within Swedish healthcare that implements precision medicine at a national level.
Collaboration:
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Ljungström V, Cortese D, Young E, Pandzic T, Mansouri L, Plevova K, Ntoufa S, Baliakas P, Clifford R, Sutton LA, Blakemore S, Stavroyianni N, Agathangelidis A, Rossi D, Höglund M, …, Rosenquist R. Whole-exome sequencing in relapsing chronic lymphocytic leukemia: clinical impact of recurrent RPS15 mutations. Blood. 2016 Feb 25;127(8):1007-16.
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Mansouri L., Sutton LA., Ljungstrom V., Bondza S., Arngarden L., Bhoi S., Larsson J., Cortese D., Kalushkova A., Plevova K., Young E., Gunnarsson R., Falk-Sorqvist E., Lonn P., Muggen A., Yan XJ., …, Rosenquist R.: Functional loss of IκBε leads to NF-κB deregulation in aggressive chronic lymphocytic leukemia. J Exp Med. 2015 Jun 1;212(6):833-43.
Panagiotis Baliakas, MD, PhD, Uppsala University, Uppsala University Hospital, Sweden
Dr. Baliakas works at the Department of Immunology, Genetics and Pathology, Uppsala University and the Department of Clinical Genetics, Uppsala University Hospital. He has been coordinating several key cytogenomic studies focusing on the diagnostic and prognostic value of chromosomal defects in leukemia. His current research interest is focused also on germline syndromes that predispose to cancer. He is interested in the pathogenesis of myeloid neoplasms in adults that carry germline pathogenetic variants in genes associated with increased risk for development of hematological malignancies.
Collaboration:
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Baliakas P, Jeromin S, Iskas M, Puiggros A, Plevova K, NguyenKhac F, Davis Z, Rigolin GM, Visentin A, Xochelli A, Delgado J, Baran-Marszak F, Stalika E, Abrisqueta P, Durechova K, et al. Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations and clinical impact. Blood. 2019 Mar 14;133(11):1205-1216.
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Baliakas P., Iskas M., Gardiner A., Davis Z., Plevova K., Nguyen-Khac F., Malcikova J., Anagnostopoulos A., Glide S., Mould S., Stepanovska K., Brejcha M., Belessi Ch., Davi F., et al: Chromosomal Translocations and Karyotype Complexity in CLL: A Systematic Reappraisal of Classic Cytogenetic Data. Am J Hematol. 2014 Mar;89(3):249-55.
Andreas Agathangelidis, PhD, National and Kapodistrian University, Athens, Greece
Dr. Agathangelidis is an assistant professor of genetics and principal investigator at the National and Kapodistrian University, Athens, Greece. He is involved in the studies of the immune repertoire in different types of diseases as well as in the general population. He is an expert in the application of modern methods of genomic and transcriptomic analyses and the design of analytical methods for the processing of large-scale biological data.
Collaboration:
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Agathangelidis A, Chatzidimitriou A, Gemenetzi K, Giudicelli V, Karypidou M, Plevova K, Davis ZA, Yan XJ, Jeromin S, Schneider C, Pedersen LB, Tschumper R, Sutton LA, Baliakas P, Scarfò L, et al. Higher-order connections between stereotyped subsets: implications for improved patient classification in CLL. Blood. 2021 Mar 11;137(10):1365-1376.
Prof. Kostas Stamatopoulos, MD, PhD, Centre for Research and Technology Hellas, Thessaloniki, Greece
Prof. Stamatopoulos is the director of the Institute of Applied Biosciences at Centre for Research and Technology Hellas (CERTH), Thessaloniki, Greece. He has been involved in lymphoma research since the late ‘90s and is a founding member of important scientific initiatives in the field. He has published extensively about the immunobiology of chronic lymphocytic leukemia and other lymphomas in several peer-reviewed journals. His current research interests focus on the role of microenvironmental interactions in human lymphomas and the study of antigen receptor gene repertoires in health and disease. Since 2018, he coordinates the Hellenic Precision Medicine Network in Oncology.
Collaboration:
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Ntoufa S, Gerousi M, Laidou S, Psomopoulos F, Tsiolas G, Moysiadis T, Papakonstantinou N, Mansouri L, Anagnostopoulos A, Stavrogianni N, Pospisilova S, Plevova K, Makris AM, Rosenquist R, Stamatopoulos K. RPS15 mutations rewire RNA translation in chronic lymphocytic leukemia. Blood Adv. 2021 Jul 13;5(13):2788-2792.
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Papakonstantinou N, Ntoufa S, Tsagiopoulou M, Moysiadis T, Bhoi S, Malousi A, Psomopoulos F, Mansouri L, Laidou S, Papazoglou D, Gounari M, Pasentsis K, Plevova K, Kuci-Emruli V, Duran-Ferrer M, …, Stamatopoulos K. Integrated epigenomic and transcriptomic analysis reveals TP63 as a novel player in clinically aggressive chronic lymphocytic leukemia. Int J Cancer. 2019 Jun 1;144(11):2695-2706."